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Query: [B] KOG4140 Nuclear protein Ataxin-7, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSERAADDVRGEPRRAAAAAGGAAAAAARQQQQQQQQQQPPPPQPQRQQHPPPPPRRTRPEDGGPGAASTSAAAMATVGERRPLPSPEVMLGQSWNLWVEASKLPGKDGTELDESFKEFGKNREVMGLCREDMPIFGFCPAHDDFYLVVCNDCNQVVKPQAFQSHYERRHSSSSKPPLAVPPTSVFSFFPSLSKSKGGSASGSNRSSSGGVLSASSSSSKLLKSPKEKLQLRGNTRPMHPIQQSRVPHGRIMTPSVKVEKIHPKMDGTLLKSAVGPTCPATVSSLVKPGLNCPSIPKPTLPSPGQILNGKGLPAPPTLEKKPEDNSNNRKFLNKRLSEREFDPDIHCGVIDLDTKKPCTRSLTCKTHSLTQRRAVQGRRKRFDVLLAEHKNKTREKELIRHPDSQQPPQPLRDPHPAPPRTSQEPHQNPHGVIPSESKPFVASKPKPHTPSLPRPPGCPAQQGGSAPIDPPPVHESPHPPLPATEPASRLSSEEGEGDDKEESVEKLDCHYSGHHPQPASFCTFGSRQIGRGYYVFDSRWNRLRCALNLMVEKHLNAQLWKKIPPVPSTTSPISTRIPHRTNSVPTSQCGVSYLAAATVSTSPVLLSSTCISPNSKSVPAHGTTLNAQPAASGAMDPVCSMQSRQVSSSSSSPSTPSGLSSVPSSPMSRKPQKLKSSKSLRPKESSGNSTNCQNASSSTSGGSGKKRKNSSPLLVHSSSSSSSSSSSSHSMESFRKNCVAHSGPPYPSTVTSSHSIGLNCVTNKANAVNVRHDQSGRGPPTGSPAESIKRMSVMVNSSDSTLSLGPFIHQSNELPVNSHGSFSHSHTPLDKLIGKKRKCSPSSSSINNSSSKPTKVAKVPAVNNVHMKHTGTIPGAQGLMNSSLLHQPKARPLast
1 -240.000[B] KOG4140 Nuclear protein Ataxin-7  ali  100  1MSERAADDVRGEPRRAAAAAGGAAAAAARQQQQQQQQQQPPPPQPQRQQHPPPPPRRTRPEDGGPGAASTSAAAMATVGERRPLPSPEVMLGQSWNLWVEASKLPGKDGTELDESFKEFGKNREVMGLCREDMPIFGFCPAHDDFYLVVCNDCNQVVKPQAFQSHYERRHSSSSKPPLAVPPTSVFSFFPSLSKSKGGSASGSNRSSSGGVLSASSSSSKLLKSPKEKLQLRGNTRPMHPIQQSRVPHGRIMTPSVKVEKIHPKMDGTLLKSAVGPTCPATVSSLVKPGLNCPSIPKPTLPSPGQILNGKGLPAPPTLEKKPEDNSNNRKFLNKRLSEREFDPDIHCGVIDLDTKKPCTRSLTCKTHSLTQRRAVQGRRKRFDVLLAEHKNKTREKELIRHPDSQQPPQPLRDPHPAPPRTSQEPHQNPHGVIPSESKPFVASKPKPHTPSLPRPPGCPAQQGGSAPIDPPPVHESPHPPLPATEPASRLSSEEGEGDDKEESVEKLDCHYSGHHPQPASFCTFGSRQIGRGYYVFDSRWNRLRCALNLMVEKHLNAQLWKKIPPVPSTTSPISTRIPHRTNSVPTSQCGVSYLAAATVSTSPVLLSSTCISPNSKSVPAHGTTLNAQPAASGAMDPVCSMQSRQVSSSSSSPSTPSGLSSVPSSPMSRKPQKLKSSKSLRPKESSGNSTNCQNASSSTSGGSGKKRKNSSPLLVHSSSSSSSSSSSSHSMESFRKNCVAHSGPPYPSTVTSSHSIGLNCVTNKANAVNVRHDQSGRGPPTGSPAESIKRMSVMVNSSDSTLSLGPFIHQSNELPVNSHGSFSHSHTPLDKLIGKKRKCSPSSSSINNSSSKPTKVAKVPAVNNVHMKHTGTIPGAQGLMNSSLLHQPKARP 892
2 -12.400[R] KOG2350 Zn-finger protein joined to JAZF1 (predicted suppressor)  ali follow..  650..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SKYAAGQELMQRQREEQLKYWLDVGMHKKQEDPKTLKSPQKPAPPADQASTSSASTSGSGSGSSSMQPPKRMPAHLKRGSAASSPGVQSKGTENGTNGSNSSSSNSKNVAKKSADQPLSTLANTRERRSEYGQKRNVSGSRLAATPASKRKLSSKDVEQAADAPEVLTHSDNAVDVGIIDDECGGFGAVGVMNGVASPVANNSEMDTEAEVEAEPTATKAITIHCQQPVTTPVAAAATANERLPGVAPHRRGPRRADRREEELVASAPGYRCRPSMRGADAGAAAAAAAAPTHPHPHRPPPPPP-P 954
3 -11.500[O] KOG0802 E3 ubiquitin ligase  ali follow..  11  317.......NIRALLSAILKRIK-------GYIKLRIALGALHAALPDATSE----------------RAYDDECAICPMAKAKRLHCNHLFH-RSW--------------------------------LDQGLNE--------------SCPTCRKPLFVGRTENEVNPRTVEVSSDEQLARQLERQNNPVHALATGLFPAEVPDSVENDTSRNLGLDPSWLQTWSSQGSDVAGPSTTSRTVGLGRVQMMMRHLASVGESYAQTALDDAAWSLWPMNPSQASTSSTTVPPGNGGRTGGLHLRTVSNTTNESLTNILAMAETVREVMPHVPDEIIFQVN........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 586
4 -10.300[R] KOG4227 WD40 repeat protein  ali follow..  13  579ASTWQRNAMRRRQKTTREDKPSAPIKPTNTYIGEDNYDYPQIKVDDLSSSPTSSPERSTSTLEIQPSRASPTSDIESVERKIYKAY----------KWLRYSYISYSNNKDGETSLVTGEADEGRAGTSHKD----------------------------------NPAPSSSKEACLNIAMAQRNQDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGSVEHPFETKKLNGKALSSRAEEPPSPPVPKASGSTLNSGSGNCPRTQSDDSEERSLETICANHN--------NGRLHPRPPHPHNNGQNLGELEVVAYSSPGHSDTDRDKDC----------CGSEMACETPNAGTRRAVHGHS------LKRQRIELEDTDSENSSSEKK...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 939
5 -10.100[O] KOG0717 Molecular chaperone (DnaJ superfamily)  ali follow..  194.......DITQASNRFESRQIDQENKKFRDVGKQERNEQIRNLVAFVRKRDPRVKAYREILEQKKLEAHKKQADNRKKQIAKNQELANSYLNDKEAEAARLAHLIEVSLQMAEDYDTCSDECDE------------------EGEELPYCVVCSKSFKTVAKLNH-SKQH-------------------------------------------------------------IRQLNELKKHMKEEDSTIFTEAEPKPDETPKGKKNKRKDRKKGNGIFDVEETEAVEAEIQEAPPVENEQPEEEEKECTPEVVKKEKKKRRADKNQNPSATVEEEAPKSTEPKSAICDK--------C-------------REVFDSRTRLFAHLQETGHATLLINKPGEKGQKKAKNKKGQRGNKGD.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 506
6 -9.950[TU] KOG3895 Synaptic vesicle protein Synapsin  ali follow..  12  407..........................................................................................................................................................................................................................................................................................................................................................CGLVVAKDGREYIISACDSTFALIGDTQEEDRRQIADLVSGRMQNVCRPSMAQTGPGKLPSRSSVSSRAESPTDEGVAPTPPLPAGPRPAPMGGPPPIPERTSPAVGSIGRLSSRSSISEVPEEPSSSGPSTVGGEIANKKRGRTASETSSGSGPGSVPSSAGPGSGFSSSFLG------------------------AGKGEGVISTQPTQRPSEEPPAIPTTASSAVRPESSVSVSDSRNTDTLTERAGAGYQPVTNYEQQERVNPFDKEPSKSGSAASIHTSSSSSISSSSISSRINRNGNAIQSPPPPAGPPPPPPTNVTAVGSNANSSSGYRNSFSSSLSKDKTSYGNYGSTTSVETITRMDTNTTNIGATATEAGEASGVTAITNISNSDGIVAPTTGTITTSVTTNDWRSAIGMRSASVYSAPAAVTTVLPGDTSGYDSNSIASQGEGLNNPSDLPSYTRPSYSRSESNASKHSDLDVIFGDSKTTPASYGNGKYTRAAGSISDADMIFGGPPSNYKTDRFGASKSMSMTS........ 927
7 -9.470[R] KOG1280 Uncharacterized conserved protein containing ZZ-type Zn-finger  ali follow..  15  386FCSMLADE--GLPWTAN--PSGSVKSNGKLLLYPVKTKELMERFYRGLAEYKTWITAESKATELPSA-STSSAYFTVLGD---IP----YADSGSD------DLESNASEEMASDLHGEGNSDDLAGLEEDEVMYCGQCRIKSFLDKFNCVFCKKRFSAEELQLHLSEMHSNPAD............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 624
8 -9.430[KD] COG5189 Putative transcriptional repressor regulating G2/M transition  ali follow..  1M------DF---TTMTMASNMATSTTTTATSAHASINSSSNFNIDIDSNQNTPSILINNNSDSSNGKNTDFNGVNNI--RRESIAHSQGMGGVSWGSWL------------------------------RDEIISRRYLPNLEDY---SC--CGLSL--HDLLRHYEEAHISTSPNTTNMSQIPMNSAGNTSSSVRMTNNTSSANYNLQNNMAANTKNAGHKTNTMQAHSSNATNNTSINNMHANLQSNMDSNSTIRQSQHPHHQQNIIQQQLQSNSVNHTSGAVPTPSVMGSATASSTTANPNVISITGAPNSGLSMANHSQ......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 377
9 -9.280[S] COG5445 Predicted secreted protein  ali follow..  1MNWRRI---------LLALVTLPTLAEETPLQLV----------------------RGAQHDQLYQLSSSGVTKVSALPDSLTTP-----LGSLWKLYVYAWLEDTH--------------------QPEQPYQCRGNSP--EE---VYCRSCGLYFAPQRLHIGADVWGQYWQQRQAPAWLASLTTLKPETSVTVKSLLDSLATLPAQNKAQEVLLDVVLDEAKIGVASMLGSRVRVKTWSWFADDKQEIRQGGFAGWLTDGTPLWVTGSGTSKTVLTRYATVLNRVLPVPTQVASGQCVEVELFARYPLKKITAEKSTTAVNPGVLNGRYRVTFTNGHLDREEYVRVLDREAKSTPPEAA--KAMTVAIRQNANREGDCLTI--QRVSASPATTGARTMTAWTQ...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 393
10 -9.090[Q] COG4647 Acetone carboxylase, gamma subunit  ali follow..  10  2VMSKYTQEQIKNDWNTVLKMLSMPKDHERFQMYLKVLQDKVDFDDKIVLPLGPHLFVVQDAQKKWVIKCSCGHAFCAPEE----------------NWKLHANIYVRDTAEKMEEVYPKLLASDTHWQVYREY---------------ICPDCGILLDVEAPTP........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 140

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Robinson-Rechavi M, Godzik A. Structural Genomics of Thermotoga maritima Proteins Shows that Contact Order Is a Major Determinant of Protein Thermostability. Structure (Camb). 2005 Jun;13(6):857-60.