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Query: [S] KOG4149 Uncharacterized conserved protein, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MFAKNLLFRFPKCIRINGYNNMRRSLLQRNGFQAGICRKFGTATKTDVWKGRFLPIVSGVAAASLTAGYLLGKNTSNASSSQDNDHPVVGEHVHTETQSYNEPYMQRHRIEDAIEKKMTSETQPSTDEKGRKVSATENSAPKKTDKEKSSGETAGNILREQIATGKDDDEYARKFEEVEEESSEESAFNPDTGEINWDCPCLGGMAHGPCGEEFKAAFSCFVYSKSEPKGMECLDKFQAMQACFQKHPEIYQDMVGESEEEDAETNEKPSTTSDENNQPQSPPSDNASNPEEDVMNMEKEIVNLTPMSVIKEILast
1 -101.000[S] KOG4149 Uncharacterized conserved protein  ali  100  1MFAKNLLFRFPKCIRINGYNNMRRSLLQRNGFQAGICRKFGTATKTDVWKGRFLPIVSGVAAASLTAGYLLGKNTSNASSSQDNDHPVVGEHVHTETQSYNEPYMQRHRIEDAIEKKMTSETQPSTDEKGRKVSATENSAPKKTDKEKSSGETAGNILREQIATGKDDDEYARKFEEVEEESSEESAFNPDTGEINWDCPCLGGMAHGPCGEEFKAAFSCFVYSKSEPKGMECLDKFQAMQACFQKHPEIYQDMVGESEEEDAETNEKPSTTSDENNQPQSPPSDNASNPEEDVMNMEKEIVNLTPMSVIKEI 313
2 -15.100[O] KOG1645 RING-finger-containing E3 ubiquitin ligase  ali follow..  9  12.........................................................................................................HGGTIARFIEFGEAFGHYGEEEDEEEEDEEEAYVDYGEVQEEDEEEEEEEDSERQTREYIDVLDSPVRVSQNESEGIENQNRRMSNGNKVTLRDCLVLSVWKFKSGILD---IVFPVDMDIPASTSGF--------SDEVE---IYASRVAAVDDEAHKRILFLEAKLRSIEQKTASWSNKEVQWKITEAELRLEVTKLKKKIANME. 223
3 -13.300[C] KOG3458 NADH:ubiquinone oxidoreductase, NDUFA8/PGIV/19 kDa subunit  ali follow..  10  50....................................................................................................................................................................................QELDDPRACLAEGKAVTSCDFFRKVKK-TCHEEFTQYATCLDKSSGTMAFSHCRKTQGVFDKCIKDNFDWDRPSYGYFSRAKVIQSAREAPKKEEKVSYPDATPGLPEDYPKPPAK................. 166
4 -12.300[S] KOG4695 Uncharacterized conserved protein  ali follow..  16  47.............................................................................................................................................................................................................ASSSCTQELQALFGCLKKWEFDDV--PCSKQHTLYMDCVHKGAEEAAAYRDATRKGTLGESGAGGKQSMTSAQ................................... 117
5 -11.700[O] KOG0824 Predicted E3 ubiquitin ligase  ali follow..  17  2................................................................................................................................................................................NASTSSPSQQLQQAINSTIDKECAVCYSEMILPCGHKF--CFICLKGVSVSNN-GDC---------C...................................................................... 63
6 -11.300[O] KOG1813 Predicted E3 ubiquitin ligase  ali follow..  11  237..............................................................................................................................................................EKEWEEAEKVRKRNKAMGVEDEDDEADKDSDEDENALPFACFICREPFVDPCKHYF---EHCALK----TKNKKC---------CNQPTMGIFNAAHEIKKRMAEERSKAEQGLRRLWPVGEVVPKSK........................... 357
7 -11.200[O] KOG0823 Predicted E3 ubiquitin ligase  ali follow..  12  45...............................................................................................................................EVIVSRIREREITTTTTPALVSPNEHRDSTAGVIHERSRERLVENGENKTYLIAKALNMEKTSSVPGGFFDCNICLEKAEDPCGHLF----GCFYQ-LIYLNIKEC---------CDGE--PIYGNGDDCDGTKPKLEDCGISLPPRPNAKRVESVRQK........................... 204
8 -10.900[S] COG5291 Predicted membrane protein  ali follow..  12  179...............................................................GIVVGHLFHYRKGITIREGRERHERNMGYSNASTTSGDSMASLTDMADTKSSTENSAVTEESQCCAESFKDSSVVSSQKSMAVSTVVGSSTEAKNNYLDFTEALCDKEVVAEQNPESQSNEEWDEKWGDSDNESECS................................................................................................................. 348
9 -10.400[R] COG5084 Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins  ali follow..  15  276.....................................................................................................................................................................................................NCRCFEFAKYGFCEL------SC-----KNQHILQCTDYAMF-PQCSLYHGAVSADVPEQTEAPISKTAGSINPEDSGSEIGSNSLESNLD......................... 373
10 -10.400[R] COG5152 Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers  ali follow..  11  221.....................................................................................................................................................................DREWDSVQEKYKKGAKLEEGMVKNEKKEDIPFVCLICKKDYRSPCGHHF---EQCAITRYRKTP--TC---------CGADTKGLFSVDKNFDRLLKNRKSKNDEAVKQKVGGFESNNSATTEVSERKDREA................ 345
11 -10.000[K] KOG4218 Nuclear hormone receptor betaFTZ-F1  ali follow..  13  2................................................................................................................................................................SSNSDTGDLQESLKHGLTPIVSQFKMVNYSYDEDLEELCPVCGDKVSGSCKGFFKRTYTCIENQNDKTQRKRC--PYCRFQKCLSVGMK--LEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTISSA.. 166
12 -10.000[O] KOG0317 Predicted E3 ubiquitin ligase, integral peroxisomal membrane protein  ali follow..  16  224........................................................................................................................................STLGSWIYGRKRTNDSITRSSVGLQERSEHESIEGIPKESQLTHINLSDKNQLPFIPEASRKCILCLMNMSDPCGHLF--CWSCLMSWCKERP--EC---------C...................................................................... 323
13 -10.000[S] KOG4618 Uncharacterized conserved protein  ali follow..  15  11..........................................................................................................TSSLSTISNGMTMTNDNRDTTNTNSGSTSSNNSQPSSSSTPPAASGPVTDRTKVNYVPKSDDPSSFQYYPDDPENPVNKYKFALKADSQYYD----------PCEESSKLSFQCLERNDYD---SKCQEYFDAYREC...................................................................... 135
14 -9.970[T] KOG3575 FOG: Hormone receptors  ali follow..  10  2....................................................................................................................................................................SPLKMHVNMLQSDHALIMSSFPEPSPSSKRPTENCKVCGDRPNNGCTVFFRRAVNCLISCTYRNACRYC-----RFQKCFAV--------MHSSAIQRRDLVGPRKISGDGEVIICENNTFLDDFASFQRTQFAEHLQYFTEHQVDVAF 159
15 -9.680[R] KOG3362 Predicted BBOX Zn-finger protein  ali follow..  10  1MIAQSKLFQGKNRLSSKLFKNSYLNCRRNEANGMQPRSIEVGGRHFSDIKCAFSKLIFLFLSTILISKM---FAPSRKPAATANQLRASSRISNLEGNRTLDENARRNRRNRQLDGLEQDNSHDDPHANLVWNKNAPKFDDEMIGGPSAKKAKKVKEDKSGIVHGEKARRRKLARPEFNKQRFKKSFNAHVIEQS---CAV--------CG--IISKYCC-----------RCGAKYCSL-PCRDVHND................................................................ 255
16 -9.600[K] KOG2478 Putative RNA polymerase II regulator  ali follow..  11  373.........................................................................................................NHEPEEEEEEEMETEEKEAGGSDEEQEKGSSSEKEGSEDEHSGSESEREEGDRDEASDKSGSGEDESSEDEARAARDKEEIFGSDADSEDDAD-------------------------SDDEDRGQA-----------------------QGGSDNDSDSGSNGGGQRSRSHSRSASPFPSGSEHSAQEDGSEAAASDSSEADSDSD. 531
17 -9.560[S] KOG4090 Uncharacterized conserved protein  ali follow..  18  111..............................................................................................................................................................................................................QQPCLYEIKQFLECA---QNQGDIKLCEGFNEVLKQCRLAN.................................................................. 148
18 -9.510[O] KOG3970 Predicted E3 ubiquitin ligase  ali follow..  13  45..............................................................................................................................................................................................TDQDYDPNCSCKTTLAEGNCLHLL----KCFDEATTAPAGYRC---------CVFPPINEVSPLIEKLREQLKQSNWARAALGLPTLPELNRPVPSPAPPQLKNAPVMHKEVPVHNNRSSTP. 172
19 -9.480[K] KOG4216 Steroid hormone nuclear receptor  ali follow..  12  5.........................................................................................................APGDSDLETEARVPWSIMGHCLRTGQARMSATPTPAGEGARSSSTCSSLSRLFWSQLEHINWDGATAKNFINLREFFSFLLPALRKAQIEIIPCKICGDKSSGGCKGFFRRSQNCLIDRTSRNRCQHC-----RLQKCLAV-----RDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDD.. 224
20 -9.190[S] KOG4624 Uncharacterized conserved protein  ali follow..  13  47.................................................................................................................................................................................................................CSKEVADFQECCKASS------TCRKQNSALKECLTQWEAFKEECKQIYLQERADYRSTGIPKKHRLEK................................... 117
21 -9.190[R] KOG3002 Zn finger protein  ali follow..  13  2...............................................................................................................................................APGGSALKEALESNSTGVDYEVKMAKVEANSKPTKSGSGSIGKFHSSNGVYELLECPVCTNLMYPPCPNGHTLCSSCKLRVQNT-----CRYELGNIRCCKLKHEQ................................................................ 136
22 -9.180[O] KOG1571 Predicted E3 ubiquitin ligase  ali follow..  16  256....................................................................................................................................................................KQEREEAKIRERLDTERRERRARSRPHTLSQDQLC-CSTNPKE-PCGH------LC----------EDCAQKIS--VTCIVSKAAAF.............................................................. 336
23 -9.130[C] KOG4763 Ubiquinol-cytochrome c reductase hinge protein  ali follow..  13  17.........................................................................................................................................ANAFPGDSRSTTFFQCGPNDSHRLEDERKMLTESGDPKEEEEEEGELVFLHQDPLTTVREQCQ-----QLEKCVKAQEWLELCDECVSSQSHTEECTEELFDFLHATDH-HKLFNNL........................................................... 131
24 -9.130[O] KOG0802 E3 ubiquitin ligase  ali follow..  9  343....................................................................................................................................................................................HAALPDATSEELRAYDDECAIC--MAKAHCNHLF---LGCLRSDQGLNEVYSC--------TC---RKPLFVGRTENEVNPRTVEVSSDEQLARQLERQNNPVHALATGLFPAEVPDSVENDTSRNLGLDPS. 468
25 -9.120[O] KOG0826 Predicted E3 ubiquitin ligase involved in peroxisome organization  ali follow..  11  208..................................................................................................................................................................SNDQRRKVGGTLINPEAMPRKQLPKEVQQSLPQRGECPVCLLSIQTPSGYVF-----CW----------KCISHMKEHGTCLDDLVRIYET............................................................ 297
26 -9.000[S] KOG4850 Uncharacterized conserved protein  ali follow..  13  120...........................................................................................................TQIINGSVDVDTEDRQKRKPESDGRTAKALRSLQFTNPGRQTEFAPETGKREKRRLTKNATAGSDRQVIPAKSKVYDSQGLLIFSGMD---CDCLDEDCLGACP-------AC--------GSTKC-------AECRCDRKWLYEQI........................................................... 246
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Multiple flexible structure alignment using partial order graphs. Bioinformatics. 2005 Mar 3;