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Query: [S] KOG4654 Uncharacterized conserved protein, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MTSRKRSGSGSTKRPKEKVVYIYELLCRGEDPSSESPEFWNEFFLLQPNFEALENEIGKLNNEQLQLVKPNLNTLFQRCIEMLDTDHPKRLCNSLHTLCSLFYGIFKKSNAEPTLNILNEIFGHEKMDEWLKLLMQYCNRILLGDVPENARFMCLKLLQVLVTGTDNVNQNALFEHLMMHSMFDAFVRLLSDPTFRSQHGHDIVILLTILVNYRKHEATNPYVVQLSILADELALNGYGQMISQSLIDFCRQYIQSLNNVQSSSWFSSLSNIVGNMFVSDEGCERVQQIKANNGLLLALYEAVHLNRNFITTLAHTQAESSAPPSPSNTLSLAQPVPDLSNAPIIDITQYPTNLLVAVFQYCSIVMQDNKNESSIANLKLCFLILTCISEDQYANSMMHDSNLTFKVMLHRAQMRHRKLNVDRVGKSQPLAATLLDLLVEFIVSHLMKKFPMELYLLCIGVIHRILCYQKRCRVRLNYPWKELWSALIGLLRFLVNQEQTLVKKCNIFHLSLQVVNIFNLFITYGDTFLATTNSYDELYYELNREEKVFTEIHAMGKVVKILSVETKLIIFKLVLRYTTMPDCEYKDDVIKLLNALVNILAIVKHFQNKIKEWLAEQGLSTPTEEQILDVVRKNYDLTLKLQDSLDQYERYTETPLHTNFFKLMVRDVVNDTRKHIYGYVKEAVSVIPDQEILLSSSMTSVSAGTATPASATAVPEAKALPSFALast
1 -175.000[S] KOG4654 Uncharacterized conserved protein  ali  100  1MTSRKRSGSGSTKRPKEKVVYIYELLCRGEDPSSESPEFWNEFFLLQPNFEALENEIGKLNNEQLQLVKPNLNTLFQRCIEMLDTDHPKRLCNSLHTLCSLFYGIFKKSNAEPTLNILNEIFGHEKMDEWLKLLMQYCNRILLGDVPENARFMCLKLLQVLVTGTDNVNQNALFEHLMMHSMFDAFVRLLSDPTFRSQHGHDIVILLTILVNYRKHEATNPYVVQLSILADELALNGYGQMISQSLIDFCRQYIQSLNNVQSSSWFSSLSNIVGNMFVSDEGCERVQQIKANNGLLLALYEAVHLNRNFITTLAHTQAESSAPPSPSNTLSLAQPVPDLSNAPIIDITQYPTNLLVAVFQYCSIVMQDNKNESSIANLKLCFLILTCISEDQYANSMMHDSNLTFKVMLHRAQMRHRKLNVDRVGKSQPLAATLLDLLVEFIVSHLMKKFPMELYLLCIGVIHRILCYQKRCRVRLNYPWKELWSALIGLLRFLVNQEQTLVKKCNIFHLSLQVVNIFNLFITYGDTFLATTNSYDELYYELNREEKVFTEIHAMGKVVKILSVETKLIIFKLVLRYTTMPDCEYKDDVIKLLNALVNILAIVKHFQNKIKEWLAEQGLSTPTEEQILDVVRKNYDLTLKLQDSLDQYERYTETPLHTNFFKLMVRDVVNDTRKHIYGYVKEAVSVIPDQEILLSSSMTSVSAGTATPASATAVPEAKALPSFA 724
2 -24.600[R] KOG2226 Proteins containing regions of low-complexity  ali follow..  10  1.....MGSQQSKLDFRNAVLRLHE-----ERNIPKFDLIWERLWTLPETTEDVFHLMSIDDLTKVKDNAPNLQTIIAVLWDKLEDPTTKCALNCMRLLTRLMPIIFEDKSMLRGASFLNTVVDYGVHYCIWETGVVYHPTMLKERSYELHRVEVLRLLLSLFS-RTDGNGSSCCAYVASICLLSSLINTAMRSVAHMSLIEYCFSVLLILMSEENNNGTNYFSILLSKLQPYSDFQIILDGMSRLLYPPMQSTIPKRSSLIMFDY--------------------------YPLVLIFCKLFIHYNERFFHYLIDTD-----------------------------------RAIDLFIFLLYLSFEYLGDPSTYNHLKLCVILLKRLTAEKYFCKRLNKP--------------QQQTALPISMPVPFEGGTYADFTIIAISLLVQYTKDSEIAQMLCCSLCYLCLYAQNLNSHSS-------QSLFELFQSASYP-GFLISNDVNHKILKYVIGAINNAIQY------AQKYNAPLLYFFSMHKDYIEAVSALSFDAIMSVRNSSAEGDSAYWTRNGKTFSSKAFDSILLSRLRYV------------RSKSPTPYYPIESSEFGFTNLKDVTSKDEITDGFDKALRSNSLRTHRDS------PVQPLLKQRPQLHRALTESATLHGNDRSLEDTDEAKVEPIAHSVDYTFKPTVEWWNKW. 698
3 -9.810[A] KOG1104 Nuclear cap-binding complex, subunit NCBP1/CBP80  ali follow..  9  34....................................................LESLILRVGERSTSSVESNLEGL----VSVLEADLGTFRLKILRILSDCAVRMPEK------CTVYTTLVGLLNAKN--YKFGGEFVDHMVKTFKESLKMCRWDAARYSLRFLADLVNCHVISATSLLQLLDTMIDVSNEDTVPQVRRDWFVFAVLSTL---------PWVGRDLYEKKESALESLLLRIEVYLNKRSKKHHNALRVWSSDAPHPQEEYLDCLWAQIRKLRQDNWAEKHIPRPYLVFDSILCEALQHNLPTIVPPPHHDNFEYPMPWVVYRMFDYTDCPDGPNLPGAHSIERFLIEEHLHHIIETYHHERKDCAAQLLSFPYLEYCIVEVVFAELFHMPTPRYLDICYGSILIE------LCKLQPATLPQVLAQATEILFMRIDS--------MNTSCFDRFVNWFSYHLSNFKFTWS--WDEWDSCLLFIQEVLQKCLRLSYHQRITEMMPTTYAKLINEEAANLPGTTVAHQLV-VAIRQKCTPEEVVNILKDIPNSGYSGEEMSDGSFNALKID----VQTLLNLGSKSFSHSFAAISKFHSVFRALAETEEAQICILHNIFELWSSHQQMMVVLIDKL--FSKEMTGEFTKLYLWEILHLTIKKMNKHVIKLNTELSEAKEKLAKADSSSSDSEDDSSHKRKKPITHADKPSEEVVE 703
4 -8.850[J] KOG2154 Predicted nucleolar protein involved in ribosome biogenesis  ali follow..  8  3.............LLISEIKDIAKRLTAAGD---------------RKQYNSIIKLINELVI-------------PENVTQLEEDETEKNLRFLVMSLFQIFRKLFSRTLPSSKKSTLEKEQFVNWCRKVYEAFKTKLLAIISDIFETSLGLDSLDVYLQLAELESTHFASEKGAPFFPNKTFRKLIIAL---------------WSSNMGEIEDVKSSGASENLIIVEFTEKYYTKFADIQYYFQSEFNQLLEDPAYQDLLLKNVGKWLALVNHDKHCSSVDADLEIFVPNPP-----------------------------------------------------------------------AIENESKFKSNFEKNWLSLLNGQLSLQQYKSILLILHKRIIPHFHT-------------------PTKLMDFLTDSYNLQSSNKNAGVVPILALNGLFELMK-------RFNLEYPNFYMKLYQIINFRLMDVFLSSTHLSAHLVASFIKKLARLTLESPPSAI----TVIPFIYNLIRKHPNCMIMLHNPAFISNPFQTPDQVANLKTLKENYVDHESDPELTHALDSSLWELASLMEHYHPNVATLAKI............................................................................................................ 483
5 -8.470[U] KOG0946 ER-Golgi vesicle-tethering protein p115  ali follow..  10  132........EEFDFHVRWPGVKLLTSLLKQLGPQVQQ--------IILVSPMGVSRLMDLLADSREVIRNDGVLLLQALTRSNGAIQKIVAFENAFERLLDIISEEGNSDGGIVVEDCLILLQNLLKNNNSNQNFIQRMKPWFEVGDENSGWSLMLQLVRVLVSPTNPPGATS-QKAMFQCGLLQQLCTILMATGVPADILTETINTVSEVIR--------------GCQVNQDYFASVNAPSNPPRPAIVVLLMSMVNERQPFVLRCAVLYCFQCFLYKNQKGQGEIVSTLLPSTIDATGNSVSAGQLLCGGLFSTDSLSNWCAAVALAHALQENATQKEQLLRVQLATSIGNPPVSLLQQCTNILSQGSKIQTR--VGLLMLLCTWLSNCPIAVTHFLHNSANVPFLTGQIAENLGEEEQ------QGLCALLLGISIYFLKQLIEKRIGKENFIEKLGFISKHELYSRASQMIFDHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHD--NIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATL-KSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEG........ 848
6 -8.280[J] COG5593 Nucleic-acid-binding protein possibly involved in ribosomal biogenesis  ali follow..  8  1MATLYPKPKRGQKIIFNEEGEGTIDTKPQGVMFDPGVPWYNI------PLPELHEDKKFVNVDHVSELETRGLLLLKEDSERFSETLGHGTADKRMLQTLISSGTTSDR-------ISALTLLVQESPIHAVKALETLLSICSKKSRNEATQAITTLKDLFILGSKNVTDKHLMVWAFESFLYFKYIQIIEAFDALLFVKSQMVSTIYDLLKAKPEQEQNLLKLLINKLGDKE--NKIASKASYSILQLEASHPAMK------------LVITKEIERFIFAPSTSRTSCYYTLITLNQTVLTHKQVDVANLLIEIYFVFFTKLLFALEKEEVADAPTLEKKSLQSDSKNKKSQKRKKDEDLRKEAEENVNSR------VISAVLTGVNR-----------------------------AYPFAEVNSEKFDKHMNTL-----FAITHTASFNTSVQVLMLIFQASASRDFISDRY---YKSLYESLLD-SLYLNLLYKSLIIDNNIPRVRAFIKRMVQVSAWQQPPLVTGL-----VMHQLVIATTALRSMFTN-EVFKDVEEDDVSEDQKVDSDKDGKLSDKQSHSAYVVGNVSVSTKKEHLSYDGRKRDPQYSNADGSCLWE--IHPFLNHFHPTVSLLAKSGEKILGKPNLSLHTLNHFLDKFAYRNPKKSAAARGHSIMQPLAGGLSKGYYSGVPMNSEQFTSKKQEEIPVDE...... 691
7 -7.650[S] KOG1949 Uncharacterized conserved protein  ali follow..  10  132........KARNSEVRSNAALLFVEAFPIRDPNLHAIEM-----KIQKQFEELYSLLEDPYPMVRSTGILGVCKITSKYWEMMPPTILIDLLKKV--TGELAFDTSSADVRCSVFKCLPMILDNKLSHPLLEQLLPALRYSLHDN-SEKVRVAFVDMLLKIAKFWKICPMEHILVRLETDSVSRRLVSLIFNSFLPVNQPEEVWCERCVTLVQMNHAAARRFYQYAHEHTACTNIAKLIHVIRHCLNACIQRAVREPPEDEEEEDGREKENWKSIDRSMENNKEAKLYTINKFASVLPEYLKVFKDDRCKIPLFMLMSFMPASAVPPFSCGVISTLRSREEGAVDKSYCTLLDCLCSWGQVGHIL-RVQIHDTRPVKPELALVYIEYLLTHPKNRECLLSAPRKKLNHLLK----------------------ALETSKADLESLLQTPFSEAAAPRAFGLHCRLSIHLQHKFCSEGKVYLSMLEDTGKILSFIQDQEEDYLKLHRYQQIIQTYLTVCKDVVMVGLGDHQFQMQLLQRSLGIMQTVKGFFYVSLLLDILKE--------ITGSSLIQKTDSDEEVAMLLDTVQKVFQKMLEIARSFRKQPEEGLRVSDVEELTSRCLIGIIIKSSNVVRSFLDELKACVASNDIEGIVCLTAAVIILVINAGKHKSSKVREVAATVHRKLKTFMEITLEEDSIERFLYESSSRTLGEL-LNS.. 888
8 -7.550[YU] KOG2022 Nuclear transport receptor LGL2 (importin beta superfamily)  ali follow..  8  1MDGNEI----------AHAKKLVYDLYSGSLSPQRSQQGWNQFFGALTLQMKINTQLETLSDKDLVQLFVQL-----QKLLWDDGLPALVERKVICTLASLTIKYELEKKEEASLKVIYCLFCNKLEFFNADMNAASVLNNLFPPASSRNAQLTASYINELLLELSFSIYTKENEDALFNNVFRPCSNIIVSKEKNVAALEEALNCMIAISSYSVQSVLPAFTECMDLTVNCIALDEVSEKAMNCLADLLANYSNFITQPTIERLWTILTGPWGETHLQQELEDPDSGEENDYSFLNIVIGFA---EAMLPQIIDHIQEEKSIR------LLYILASLLSFPGYAIVEEKVSWRTLEFWTTLIEDFSMSKAATDPSKDEIFKQIAFSVVE--------------------------WKMLLPSPEQWNSWPSSSRDSFNSY-RRDLGDLLESSYSIFGERLYAMYITTIENFFSDGTGSPQSL-EVSFYCLCCILEYDTN-----DSDTLDAWLTRLFETSFAIKASAFQNPQLLKTCSQLLSSCSCFLQNHPQYLNISLPVLFDALHISETSIQMTVSRSIHTLCTTCAS------HLLTEIDGFMAVVEELTPKLVYVPSVLEKIYSSVGY--------------TQRIEDIELRISYLMRLLNCILAQLQPSLYPNLEIFENVLKSC.................................. 664
9 -7.430[A] COG5181 U2 snRNP spliceosome subunit  ali follow..  7  389........KNGTPPMRKSALRQLTDQARDFGAAALFNQILPLLMERTLERHLLVKVIDRILYKLDDLVRPFTHKILVVIEPLLIDEDYYARAEGREIISNLMRPDIDHVDEYVRNTTARAFSVVASA---VPALLPFLKAVCRSKKSWQARHTGVRIIQQIALLLGCSILPHL------KNLVDCIGHGLEDEQQKVR--IMTALSLSALAEAATPYGIEAFDSVLKPLWSG--VQRHRGKSLAAFLKATGFIIPLMEPEYASHFTRRIMKILLREFNSPDEEMKKIVLKVVSQCASTD-TPEYLRTDVLPEFFHCFWSRRMASDRRSYKQVVETTVVLAQQVGSRQ------IVERVVNNFK-----DESEPYRKMTAETVDKVIGSLGVSEIDERLEELLLDGVLFA-----------FQEQSVEEKVILTCFSTVVNALGTRCKPYLP--------QIVSTILYRLNNKSANVR-------EQAADLVSSITIVLKACGEEALMRKLGVVLYEYLG------EEYPEVLGSILGAIKAIVSVRDLLPRLTPILRNRHEKVQENTIDLVGKIADRGSEYVSA-----REWMRICFELIDMLKAHKKSIRRAAVNTGPQDVLATLLNNLKVQERQNRVCTTVAIAIVAETCMPFTVVPALMADYRTPEMNVQNGVLKSLAFMFEYIGEVYAITPLLADALMDRDAVHRQTAA----SVIKHLS 1080
10 -7.360[G] KOG2175 Protein predicted to be involved in carbohydrate metabolism  ali follow..  9  138.........................................ELNKLEEIADLVTSVLSSPIRREKLALALENEGYIKKLLQLFQACENLENTEGLHHLYEIIRGILFLNKATFSDECIMDVVGCLEYDAKFKEVIPITDSELRQKIHQTYRVQYIQIILPTPSVFEENFLSTLTSFIFDEKFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQPQNRDAFFKTLAKLGILPALEIVMGMDDLQVRSAATDI---------FSYLVEFSPSMVREFVMQEAQQSDDDILLINVVIEQMICDTDPELGGAVQLMGLLRTLIDPENMLATTNKTEKSEFLNFFYNHC--MHVLTAPLLTNTSEDKCEKDFFLKHYRYSWSFICTPSHSHSH------STPSSSISQDNIVGSNKNNTICPDNYQTAQLLALILELLTFCVEHHTYH---IKNYIMNKDLLRRVLVLMNSKHTFLALCALRFMRRIINLFEPVINALLDNGTRYNL--LNSAVIELFEFIRVEDIKSL---AHIVENFYKALESIEYVQTFKGLKTKYEQEKDRQNQKLNSVPSILRSNRFRRDAKALEEDEEMWFNEDEEEEGKAVVAPVEKPKPEDDFPDNYEKFMETKKAKESEDKENLPKRTSPGGFKFTFSHSASAANGTNSKSVVAQIPPATSNGSSSKTTNLPTSVTATKGSLVGLVDYPDDEEEDEEEESSPR.. 842
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Luz JG, Hassig CA, Pickle C, Godzik A., Meyer BJ, Wilson IA. XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. Genes Dev. 2003 Apr 15;17(8):977-90. Epub 2003 Apr 02.