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Query: [A] KOG4676 Splicing factor, arginine/serine-rich, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSNTTVVPSTAGPGPSGGPGGGGGGGGGGGGTEVIQVTNVSPSASSEQMRTLFGFLGKIDELRLFPPDDSPLPVSSRVCFVKFHDPDSAVVAQHLTNTVFVDRALIVVPYAEGVIPDEAKALSLLAPANAVAGLLPGGGLLPTPNPLTQIGAVPLAALGAPTLDPALAALGLPGANLNSQSLAADQLLKLMSTVDPKLNHVAAGLVSPSLKSDTSSKEIEEAMKRVREAQSLISAAIEPDKKEEKRRHSRSRSRSRRRRTPSSSRHRRSRSRSRRRSHSKSRSRRRSKSPRRRRSHSRERGRRSRSTSKTRDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERERSTSKKKKSKDKEKDRERKSESDKDVKQVTRDYDEEEQGYDSEKEKKEEKKPIETGSPKTKECSVEKGTGDSLRESKVNGDDHHEEDMDMSDLast
1 -59.900[A] KOG4676 Splicing factor, arginine/serine-rich  ali  100  1MSNTTVVPSTAGPGPSGGPGGGGGGGGGGGGTEVIQVTNVSPSASSEQMRTLFGFLGKIDELRLFPPDDSPLPVSSRVCFVKFHDPDSAVVAQHLTNTVFVDRALIVVPYAEGVIPDEAKALSLLAPANAVAGLLPGGGLLPTPNPLTQIGAVPLAALGAPTLDPALAALGLPGANLNSQSLAADQLLKLMSTVDPKLNHVAAGLVSPSLKSDTSSKEIEEAMKRVREAQSLISAAIEPDKKEEKRRHSRSRSRSRRRRTPSSSRHRRSRSRSRRRSHSKSRSRRRSKSPRRRRSHSRERGRRSRSTSKTRDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERERSTSKKKKSKDKEKDRERKSESDKDVKQVTRDYDEEEQGYDSEKEKKEEKKPIETGSPKTKECSVEKGTGDSLRESKVNGDDHHEEDMDMSD 484
2 -25.100[R] KOG4454 RNA binding protein (RRM superfamily)  ali follow..  12  4.......................KPTPSPPEERTIYVANFSEEVDEELLEELFIQAGPVVKVIL-----DVRDSNAKFALVEFEDELSVLFAIEMNGVRLFNQELQVKPRNG-------------------------------------------------------------TNQEELYKRKKGEIEERVRSVAAPDRDGRRDSYRDDRNRNRNGNNRDSWQQQQPPRHHRQYDPLPPPPPPPLMGGSGGHWRSGGERGPPQYSTPQMLPHQHFVNQMMQQQINRSAPPYNGRHQNSTPHRHHDRHGYDRSSSRHHRNDDRRRSAHFLDIRKFQAPPTSWAFGNFQCFFWNLFSKITYLQE.......................................................................................................................... 278
3 -24.100[A] KOG4209 Splicing factor RNPS1, SR protein superfamily  ali follow..  17  69.......................PEEKAEADAKSVYVGNVDYGATAEEIEQHFHGCGSVSRVTIQ--CDRFSGHPKGFAYVEFTEKEGMQNALAMTDSLLRGRQIKVDPKRT.................................................................................................................................................................................................................................................................................................................................................................................... 155
4 -22.800[A] KOG0113 U1 small nuclear ribonucleoprotein (RRM superfamily)  ali follow..  14  102................................RTLFIARINYDTSESKLRREFEFYGPIKKIVL---HDQESGKPKGYAFIEYEHERDMHAAYHADGKKIDSKRVLV--------------------------------------------------------------------------------------------------------DVERARTVKGWLPRRLGGGLGGTRRGGNDVNIKHSGREDNERERERYRLEREREDREGPGRGGGSNGLDARPGRGFGAERRRSRSRERRDRERDRGRGAVASNGRSRSRSRERRKRRAGSRERYDEFDRRDRRDRERERDRDREREKKKKRSKSRERESSRERRERKRERRDRERGTGSGGDVKERKPDFRDMDVIKIKEEPVDDGYPTFDYQNATIKREIDDEDEEKYRPPPAHHNMFSVPPPPILGRGNASTNPNPDNGQQSSGDPSWWRQ 448
5 -22.500[A] KOG2217 U4/U6.U5 snRNP associated protein  ali follow..  10  3..............................................................................................................................................................................................................SSSSGKKHKKDKKNRHRSRSSERPRRVTEDEDVTLDLTDDSSSRHRHHKHKKHKEHRHKHHKQKERERANEVISLEESDSDSSEVPVQAQVQAQAKLRDARESSNRDKERDSGRDRELLRERERERDRERERDRDREKEREREREKERLREREREREREKERIREREKERLRERERERERERVRELTAPPPPQISKHAEYESRREREIERERDARKRSGRERERERNRERSRSQSPASSSRKPATKEREPSSRSFSPIPENGAGDVLSITETNKLRAK 284
6 -22.400[R] KOG0126 Predicted RNA-binding protein (RRM superfamily)  ali follow..  11  36................................AWIFLGGLPYELTEGDIICVFSQYGEIVNINLV--RDKKTGKSKGFCFLCYEDQRSTILAVNFNGIKIKGRTIRVDHVSN---------------------------------------------------------------------------YRAPKDSEEIDDVTRQLQEKGCGARTPSPSLSESSEDEKPTKKHKKDKKEKKKKKKEKEKADREVQAEQPSSSSPRRKTVKEKDDTGPKKHSSKNSERAQKSEPREGQKLPKSRTAYSGGAEDLERELKKEKPKHEHKSSSRREAREEKTRIRDRGRLQMHILAGIMGVLKGVVIEVEVGAEINPIGIKGPDAPGRGVLRIPVTVGVTEDFSCTVDLE............................................................................... 332
7 -22.400[A] KOG0108 mRNA cleavage and polyadenylation factor I complex, subunit RNA15  ali follow..  19  2...........................SMTAGNVVFVGNIPYDVSEQQMTEIFNQVGPVKTFKLV---DPETGSGKGYGFCEFFDSETTAMAVRLNNSELGPRKIRVEFPSNDPRRNQSYE........................................................................................................................................................................................................................................................................................................................................................................... 94
8 -22.000[R] KOG0114 Predicted RNA-binding protein (RRM superfamily)  ali follow..  26  12.............................EVNRLLYVRNLPYKITSDEMYDIFGKFGAIRQIRV-----GNTPETRGTAFVVYEDIFDAKNACHLSGFNVCNRYLVVLYYQS.................................................................................................................................................................................................................................................................................................................................................................................... 90
9 -22.000[J] KOG0899 Mitochondrial/chloroplast ribosomal protein S19  ali follow..  17  62...............................STKLYIGGLSPGTDEHSLKDAFSSFNGVTEARVM--TNKVTGRSRGYGFVNFISEDSANSAISMNGQELNGFNISVNVAKD.................................................................................................................................................................................................................................................................................................................................................................................... 141
10 -21.800[A] KOG0121 Nuclear cap-binding protein complex, subunit CBP20 (RRM superfamily)  ali follow..  24  29...............................SCTLYVGNLSFYTTEEQIHELFSRCGDVRVIVM----DKYKKTPCGFCFVEYYVRSEAEAAMRVNGTRLDDRLIRV......................................................................................................................................................................................................................................................................................................................................................................................... 103
11 -21.800[A] KOG4207 Predicted splicing factor, SR protein superfamily  ali follow..  20  14................................ITLKVDNLTYRTSPDSLRRVFEKYGRVGDVYI---LEPHTKAPRGFAFVRFHDRSDAQDAEAMDGAVLDERELRVR-----------------------------------------------------------------------------------------------------------------------------ARYGRRDLPRSSQEEPRGRSWGGRYGRRSGSPRGRHRSQSRGPSYSRSRSRSHYGGSRYSLSIYRRSRYSRSPYRRSHYRGSRYGRSPYSRSYSRHHYSRSPYRESRYRRSPYIRSSRSRSPYRRSHSKSGSHSASPSTSKSSS........................................................................................................... 233
12 -21.500[A] KOG4849 mRNA cleavage factor I subunit/CPSF subunit  ali follow..  9  490...............................................................................................................................................................................................................................................................................KQSKVAHDERCKILISSLQDTLHGIEAKSYNRRERSRSRERSHRSRQRRERSTSRYRERSRERERDRDRERERDGGRSVRPRKSPEPVVAEAAEAPSSKRYYEDRERYRSSDRER-RDRDRDRDRERERDRDRHFTNDGRGLPLDPSNFTSQNPGNIKTGRPKSAAVAGGSMEKPRGQSAWDIIDTDAHWIIKQQTTSIPAPPSSQQN..... 696
13 -20.600[R] KOG0125 Ataxin 2-binding protein (RRM superfamily)  ali follow..  20  99...................TQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERG----SKGFGFVTFENSADADRARELHGTVVEGRKIEVNNATARVMTNKK............................................................................................................................................................................................................................................................................................................................................................................. 195
14 -20.300[R] KOG4208 Nucleolar RNA-binding protein NIFK  ali follow..  15  2...........................AAFSRSAGPILSLNP-QEDAELQKEVAQCDTVTRFRLS--RKKRTGNSKGYAFVEFESEDVAKIVTTMNSYLFGERLLECH........................................................................................................................................................................................................................................................................................................................................................................................ 80
15 -20.300[S] KOG4610 Uncharacterized conserved protein  ali follow..  13  299..................................................................................................................................................................................................................................................................KNSLVIILQLYRLYVVNAEFWKNRRESRMAKSRQFQSRRKVQDADQNSIYMISNERGGDVKKKIKRAKDKDYAEQEAVYSKKKKDKKDKKKRKRKDTGYSTASSQNLYSTKASGTDKDTRRKDKKGKKSKRTCSSSPSDCDLAKKQKRKNADKNDKKKSRKIEAVVEESSSSSSSSSDSSNSTLPSYEVIDEKKARRRKHRGSSSDTSSGDSSSSSSSSSSSDSS. 523
16 -20.300[R] KOG0118 FOG: RRM domain  ali follow..  21  165........................AQREDVIRRTVYVSDLDQQVTEEQLAGLFVSCGQVVDCRICGDPNS----VLRFAFIEFTDEEGAMTALNLSGTMLGFYPVKVLPSKT.................................................................................................................................................................................................................................................................................................................................................................................... 248
17 -20.000[R] KOG0130 RNA-binding protein RBM8/Tsunagi (RRM superfamily)  ali follow..  18  73................................WILFVTSIHEEAQEDEIQEKFCDYGEIKNIHL----DRRTGFSKGYALVEYETHKQALAAKALNGAEIMGQTIQV......................................................................................................................................................................................................................................................................................................................................................................................... 146
18 -19.700[R] KOG0226 RNA-binding proteins  ali follow..  16  204.................................RVFCGDLGNEVSDELLAKAFRKYPSFQKAKVV--RESRTNKSKGYGFVSFRDSEDYVRAMEMDGKYVGNRPIKLRKSA..................................................................................................................................................................................................................................................................................................................................................................................... 280
19 -19.500[K] KOG4661 Hsp27-ERE-TATA-binding protein/Scaffold attachment factor (SAF-B)  ali follow..  10  406................................RNFWVSGLSSTTRATDLKNLFSKYGKVVGAKVV---NARSPGARCYGFVTMSTAEEATKCIHLHKTELHGKMISVEKAKN------------------------------------------------------------EPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQDDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRLERERMERERLERERMHVEHERRREQERIHREREELRRQQELRYEQERRPAVRRPYDLDRRDDAYWPEAKRAGLDERYHSDFNRQERFHDFDHRDRGRYPDHSVDRREGSRSMMGEREGQHYPERHGGPERHGRDSRD 796
20 -19.400[A] KOG0107 Alternative splicing factor SRp20/9G8 (RRM superfamily)  ali follow..  15  4..................................VYVGNLDPRVTERELEDEFRSFGVIRSVWV-------ARRPPGYAFLDFEDSRDARDAIRVDGKNGWRVEQSHNRGGG.................................................................................................................................................................................................................................................................................................................................................................................... 75
21 -19.200[A] KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily)  ali follow..  14  4..................................VYIGRLPNRASDRDVEHFFRGYGKLSDVIM----------KNGFGFVDFQDQRDADDAVHLNGKELCGERVILEFPRR---------------------------------------------------KVGYNEERSGSGFRGREPTFRKGGERQFSNRYSRPCSTRFRLVIDNLSTRYSWQDIKDHIRKLGIEPTYSEAHKRNVNQAIVCFTSHDDLRDAMNKLQGEDLNGRKLKCTDETRDRSRSRSPRRRSRSRSPTRSRSPPARRRSPGSDRSDRKSRSASPKKRSDKRARSESKSRSRSGGRRSRSNSPPNRSPSPKKRRDNSSPRSGSAS................................................................................................................. 280
22 -19.000[J] KOG0122 Translation initiation factor 3, subunit g (eIF-3g)  ali follow..  22  212...............................ENSVRVTNLSEDTREPDLMELFHPFGAVTRVYVA--IDQKTGVSRGFGFVNFVSREDAQRAIKLNGYGYDNLILRVEWATP.................................................................................................................................................................................................................................................................................................................................................................................... 291
23 -18.600[R] KOG1457 RNA binding protein (contains RRM repeats)  ali follow..  15  81....................LFVHELKTRPGVRTLFVSGLPVDIKPRELYLLFRPFKGYEGSLI------KLTARQPVGFVIFDSRAGAEAAKNLNGIRFDPQTLRLEFAKA.................................................................................................................................................................................................................................................................................................................................................................................... 170
24 -18.100[Z] KOG3809 Microtubule-binding protein MIP-T3  ali follow..  13  120................................................................................................................................................................................................................................SSDDAVRRVLAGEKGEVKGRASLTSRSQELDNKNVREEESRVHKNTEDRGDAEIKERSTSRDRKQKEELKEDRKPREKDKDKEKAKENGGNRHREGERERAKARARPDNERQKDRGNRERDRDSERKKETERKSEGGKEKERLRDRDRERDRDKGKDRDRRRVKNGEHSWDLDREKNREHDKPEKKSASSGEMSKKLSDGTFKDSKAETETEISTRASKSLTTKTSKRRSKNSVEGRKEDNISAKSLDSIVSGINNEPNQ 379
25 -17.600[R] COG0724 RNA-binding proteins (RRM domain)  ali follow..  17  192.................................TLKIMQVNENADENSLRELLFPFAPIPRVSVV--RNKETGKSRGLAFVTFSSEEVAEQALRLDGRGYMNLILRVEWSKP.................................................................................................................................................................................................................................................................................................................................................................................... 270
26 -17.400[A] KOG0105 Alternative splicing factor ASF/SF2 (RRM superfamily)  ali follow..  25  2....................SGWADERGGEGDGRIYVGNLPTDVREKDLEDLFYKYGRIREIELKNRHG-----LVPFAFVRFEDPRDAEDAIYRNGYDYGQCRLRVEFPRT.................................................................................................................................................................................................................................................................................................................................................................................... 89
27 -17.200[A] KOG4206 Spliceosomal protein snRNP-U1A/U2B  ali follow..  15  157...............................NNILFIQNLPHETTSMMLQLLFEQYPGFKEIRMIDAKPG-------IAFVEYEDDVQASIAMPLQGFKITPQPMVISFAKK.................................................................................................................................................................................................................................................................................................................................................................................... 232
28 -16.700[K] KOG3794 CBF1-interacting corepressor CIR and related proteins  ali follow..  8  328...................................................................................................................................................................................DKKRKSKKNKRHKKHSSRTVEETDESSTGSEDSREKRGSKKRKKLKKKSKKQYDSDSLSFEGSGSDSYRLSRRRHTKHVDPSASLKSEVYHQGNSHREKHYYDEKHQKRKEIVDRPSASSDDSDYYRSNSSRKKRSEDDYKSHHRERKQVHSNDPVSEKSQKQHYSESGKIQRVEKEHRYDERRHRYVDMESENRNRSEKKPRYDDRDSEKHHRSVKGKEKHVYEASDDPEEFSDRYRSTKKTESDSESNRRSRKKKHELSSEEEEGESRVIGEQVRKSMSLIHRRLYRISGLSSVNAWNLQIRE 632
29 -16.600[A] KOG4212 RNA-binding protein hnRNP-M  ali follow..  19  640...................GAGGHAPGVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYADIKMEN----GKSKGCGVVKFESPEVAERACRMNGMKLSGREIDVRIDRNA................................................................................................................................................................................................................................................................................................................................................................................... 730
30 -16.000[R] KOG0149 Predicted RNA-binding protein SEB4 (RRM superfamily)  ali follow..  20  1MAYQPVPGSGF---------HYLNSPFGDTTFTKVFVGGLAWETQSETLRQHFEQYGEILEAVVI---DKNTGRSKGYGFVTFRDPEAARRACADPTPIIDGRRANCNLASLGRPRPPLPY........................................................................................................................................................................................................................................................................................................................................................................... 110
31 -15.700[A] KOG0120 Splicing factor U2AF, large subunit (RRM superfamily)  ali follow..  12  86.........................STITRQARRLYVGNIPFGVTEEEMMEFFNQQMHLVGLAQAAGSACQINLDKNFAFLEFRSIDETTQAMAFDGINLKGQSLKIRRPHD.................................................................................................................................................................................................................................................................................................................................................................................... 175
32 -15.700[R] KOG0153 Predicted RNA-binding protein (RRM superfamily)  ali follow..  17  226............................DRNITTLYVGNLPEEITEPELRDQFYQFGEIRSIALVP--------RQQCAFVQYTKRNAAELAAEFNKLVIQGRKVSIKWAHSQAKQGTAAK........................................................................................................................................................................................................................................................................................................................................................................... 312
33 -15.700[A] KOG1190 Polypyrimidine tract-binding protein  ali follow..  10  50.......................DSRSAGVPSRVIHIRKLPIDVTEGEVISLGLPFGKVTNLLMLKGKN--------QAFIEMNTEEAANTMVYYTSVTPRGQPIYIQFSNHKELKTDSSPNQ......................................................................................................................................................................................................................................................................................................................................................................... 144
34 -15.400[R] KOG0154 RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains  ali follow..  8  7...........................................................................................................................................................................................................................................................................NADDDGKRVQNEEGNYDPTDHQRQMEDYYKQYEEQRQVANSFHNTTGRPDLVAMQARLAETEQAIHRLNEEKKQPPPGFPIMTTPATQPEISIPRSGENKSSRSPSWAREARRSRSRSRDRRGGRSRSRSPSRRRTSRDRRDDRSSRRRRDRSHSRSRSPPSSANGSSHWSSSNRHSRRRRSRSYSRERDRNSRRDDRRSNLSNNDRYSDWNPGVPS 223
35 -15.200[R] KOG2140 Uncharacterized conserved protein  ali follow..  11  656........................................................................................................................................................................................................................................AQKPDVEQNKSSPSSSSSASSSSESDSSDSDSDSSDSSSESSSEESDSSSISSHSSASANDVRKKGHGKTRSKEVDKLIRNQQTNDRKQKERRQEHGHQETRTERERRSEKHRDQNSSGSNWRDPITKYTSDKDVPSERNNYSRVANDRDQEMHIDLENKHGDPKKKRGERRNSFSENEKHTHRIKDSENFRRKDRSKSKEMNRKHSGSRSDEDRYQNGAERRWEKSSRYSEQSRESKKNQDRRREKSPAKQ 907
36 -15.000[A] KOG2202 U2 snRNP splicing factor, small subunit, and related proteins  ali follow..  17  83..............................................EDLFEELGKFGEIESLNICDNLA---DHMIGNVYVQFKEEDQAAAALALQGRFYSGRPIIAD-----------------------------------------------------------------------------------------------------SPVTDFREATCRQYEENNCNRGGYCNFMHVKLVSRELRRKLFGRYRRSYRRGSRSRSRSRSISPRNKRDNDRRDPSHREFSHRDRDREFYRHGSGKRSSERSERQERDGSRGRRQASPKRGGSPGGGREGSEERRARIEQWNREREEKEEGGA.......................................................................................................................... 296
37 -14.900[A] KOG2253 U1 snRNP complex, subunit SNU71 and related PWI-motif proteins  ali follow..  13  18........................................................................................................................................................................................................................EKPYKLLCRASHWGIAPFFYSHSFVPSIRFISIILKLLPLLMNTNEIAIDAAAVAQGAEKELHDDREAKNRPEASKRSRRSRSSSNSSSESDSSSSRSSSYSSRSRSRTPQRSRTSKRR-RSNSHASEDSDDAREKRAFKQMMLDKKQAYLARLKRWESRERQMSKRYEREERKEKDRKKTLQKEGKRLKLFLEDYDDEKDDPKYYTSSQFFQRKRDYEREREADQKDRMQEQQEIEELKRQIMEEAANDESINIEEEARKRHKLKEE 284
38 -14.700[R] KOG2295 C2H2 Zn-finger protein  ali follow..  8  262........................................................................................................................................................................................................................................KLEGGTDEDLKVLDEKPKDPVVYERKAEQMQSVKEVEKTINSPKEEMSEADPVSTQRKPVRPVNSDGENWDDDDAENSAPKKELAEDSKDSDSKPEDKQLNKKKTKKRKRNSSDDDSSSSESSSSSDEEKLKEKYDVEDGLRAEQKTEAEKDRQEATKAKQGPQSPKLDEDEGNENTEPKGLDSKINTYEEIDNTLKSPEISSNPIKNTDNGDGSKVEEDGEKPSVGKDKVVETETIDLDKVKDGQPRALHR 513
39 -14.600[A] KOG0144 RNA-binding protein CUGBP1/BRUNO (RRM superfamily)  ali follow..  17  385....................GAAGSQKEGPEGANLFIYHLPQEFGDQDLLQMFMPFGNVVSAKVF--IDKQTNLSKCFGFVSYDNPVSAQAAIQMNGFQIGMKRLKVQLKRS.................................................................................................................................................................................................................................................................................................................................................................................... 475
40 -14.400[T] KOG1882 Transcriptional regulator SNIP1, contains FHA domain  ali follow..  8  2........................................................................................................................................................................................................................................................................KAVKSERERGSRRRHRDGDVVLPAGVVVKQERLSPEVAPPAHRRPDHSGGSPSPPTSEPARSGHRGNRARGVSRSPPKKKNKASGRRSKSPRSKRNRSPHHSTVKVKQEREDHPRRGREDRQHREPSEQEHRRARNSDRDRHRGHSHQRRTSNERPGSGQGQGRDRDTQNLQAQEEEREFYNARRREHRQRNDVGGGGSESQELVPRPGGNNKEKEVPAK 221
41 -14.400[A] KOG0145 RNA-binding protein ELAV/HU (RRM superfamily)  ali follow..  24  298.................................CIFVYNLSPDSDESVLWQLFGPFGAVNNVKVI--RDFNTNKCKGFGFVTMTNYDEAAMAIALNGYRLGDRVLQVSFKTNKAHKS............................................................................................................................................................................................................................................................................................................................................................................... 380
42 -14.300[A] KOG0124 Polypyrimidine tract-binding protein PUF60 (RRM superfamily)  ali follow..  16  216......................DQLAEEARAFNRIYVASVHQDLSDDDIKSVFEAFGKIKSCTLA--RDPTTGKHKGYGFIEYEKAQSSQDAVSMNLFDLGGQYLRVGKAVT.................................................................................................................................................................................................................................................................................................................................................................................... 304
43 -14.300[AJ] KOG0148 Apoptosis-promoting RNA-binding protein TIA-1/TIAR (RRM superfamily)  ali follow..  15  3............................DEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDT----AGNDPYCFVEFHEHRHAAAALAMNGRKIMGKEVKVNWATTPSSQKKDTS........................................................................................................................................................................................................................................................................................................................................................................... 92
44 -14.300[A] KOG0533 RRM motif-containing protein  ali follow..  12  76..................................VNISNLAPTVISSDLEELFGDYR-LSSVSVNFNEH---GDSLGTGDISLTKRDAERLVQKFSGVALDGKIMKFA........................................................................................................................................................................................................................................................................................................................................................................................ 145
45 -14.200[K] KOG2478 Putative RNA polymerase II regulator  ali follow..  12  333..........................................................................................................................................................................................................................................................................................SKRRAKAGVQSGTNALLVVKHRDMNEKELEAQEARKAQLENHEPEEEEEEEMETEEKEAGGSDEEQEKGSSSEKEGSEDEHSGSESEREEGDRDEASDKSGSGEDESSEDEARAARDKEEIFGSDADSEDDADSDDEDRGQAQGGSDNDSDSGSNGGGQRSRSHSRSASPFPSGSEHSAQEDGSEAAASDSSEADSDSD... 531
46 -14.100[O] KOG0314 Predicted E3 ubiquitin ligase  ali follow..  11  508.......................................................................................................................................................................................................................................................REEFEAKKTEMKRKRENEIRRSEGGNVVRDSEKSRIMNNSAVTSSPVKPKSRQGPPPPISSDYDRRRRSDRSSPERQSSRRFTSPPRSSSRKSERDRHHDLDSEHDRRRDRPRETDRKHRKRSEKSSSDPTVEIDDNNKSNVFTRISFPEESSGKQRKTSKSSPAPPESSVAPVSSGRRHHSRREREMVEYDSSDDEDRHFKRKPSRYKRSPSVAPSDAGDEHFRHSKRSKGERARA 744
47 -13.800[R] KOG0110 RNA-binding protein (RRM superfamily)  ali follow..  26  4..................................IIVKQLPKHITEDKLRQIFGAQGTITDLQLKYTPD---GKFRQFCFVGYSTEEEAQSAIHFDNTCIQTSRVRVESCAA.................................................................................................................................................................................................................................................................................................................................................................................... 79
48 -13.700[A] KOG0146 RNA-binding protein ETR-3 (RRM superfamily)  ali follow..  19  46........................IPMKDHDAIKLFIGQIPRNLDEKDLKPLFEEFGKIYELTVL--KDRFTGMHKGCAFLTYCERESALKAQSLHEQKTLPRPIQVKPADS.................................................................................................................................................................................................................................................................................................................................................................................... 135
49 -13.600[S] KOG2889 Predicted PRP38-like splicing factor  ali follow..  12  166........................................................................................................................................................................................................................................................................................QKRWALEEVDMLPSYKSLLDGDLVAMSDSDSEEEEVTKKEKPRLTSRRRSRSRDRERDVGDRREVREREKLKERRERGDDEPGPSSSGSGRRDDRDDRRRDRDRSRDRDRRDRRDDDRRDKKKESRRGGADNDEEREIAEANALRAKLGLAPLER................................................. 320
50 -13.400[D] KOG2186 Cell growth-regulating nucleolar protein  ali follow..  17  400........................SADRDIAQRNIFVRGFGWDTTQENLKTAFESYGEIEECSV----DKDTGRGKGYGFVMFKTRKGAREALKRPEKRMYNRIVVCNLA...................................................................................................................................................................................................................................................................................................................................................................................... 483
51 -13.400[A] KOG0128 RNA-binding protein SART3 (RRM superfamily)  ali follow..  14  581....................AVQKAAPGTEDARTIFVSNLDFTTTEDEIRQAIEGVASIRFARKANSD----LVHRGFAYVVMENDQKAQQALLKDRVPVKGRPMFISANDP.................................................................................................................................................................................................................................................................................................................................................................................... 668
52 -13.300[R] KOG2888 Putative RNA binding protein  ali follow..  7  211...............................................................................................................................................................................................................................................................EQYCREQGVTVHQLSTGRSTAGTGGGPGAAGQDADYQDYPEGGVERGSGGRGGGQAGSRSNAYPQPNNYRNDYDERDYYAAASGSSYGRGRGGYEDYPPAPLPPQMPYGERERERDRDRDKNKDYDRHRSKHKKKHNHRQSSRSRSRSRSRSRHRSERHERKRDGGGYERSSKSRHNEHYEERERRHR......................................... 398
53 -13.300[S] KOG4051 Uncharacterized conserved protein  ali follow..  8  175........................................................................................................................................................................................................................................DNNKQEKNATIKVKELPEYHTEENDSPIDVQKEPIKEVQSDEKELQREHMSEEEQKMKSTNKTAAPVRKSQRLKRSKEVKFEDEEKEEIEEDNTKDEEQKEKKEEIQEPKITHNEEVDKEKNENEEGDDEREKSTSYENTNGSESEGVDEGVDEELGYESEREAEGKGKQIESEGGNLKKKTENKKGDDQQDDTKKDSKDKNEPLAKRTRHSSSTGNTSNETSPKRKRRKAGSRKNSPPATRVSSRLRNKK. 425
54 -13.200[R] KOG3263 Nucleic acid binding protein  ali follow..  12  2..............................................................................................................................................................................................................................................................SSSRSGEHRRNYAQGRNYESSRSRGDQRDRDYREYRRNYRDERSSRRYEDSQRRDYSPARRRDR-YERHRESVREESPRRPVEHERNWQPELKHGRERFRERDYEGRRDRKERRDGVSPFSPEGEGLERKREHEKLQAPSPKEEEERPVDQGDKMDGVKEDKDGSLEVGKSHDAMTRTKSAEEEIVEQEDEATAEMKRIMGFSGFDTTTGKKHGDVGQVYKQKKTKYRQ. 229
55 -13.200[S] KOG3869 Uncharacterized conserved protein  ali follow..  11  192...............................................................................................................................................................................................................KAAEGKKKNKKNKKSKKSKKKKKNRRSSNEESSDSESNDSDDDLDRKLARQVSKLKGDQGDLKLDKLLDAKYRTISNQLDMATKKKKSKKSKKKKSSDSSDESSDEEEEPRRKHKRSHSSEDRNQRERRRSRSPRDRKKRQSRSPEQRQRQRSPEERRERRRSRSRSPLARRQRRTRSPEDRKARRQSKDTSKQREKRRSRTPEERSRSKRSRSRSSKGDDKRRIAERPPPSRPTGKPKLSEADREARLREMMDNATWREADRSQVVRKHREAYARE 468
56 -13.200[TR] KOG4019 Calcineurin-mediated signaling pathway inhibitor DSCR1  ali follow..  16  2.......................EEVDLQDLPSATIACHLDPRVCRAKFESLFRTYDKDITFQYFK--------SFKRVRINFSNPFSAADARQLHKTEFLGKEMKLYFAQTLHIGSS.............................................................................................................................................................................................................................................................................................................................................................................. 94
57 -13.000[K] KOG0147 Transcriptional coactivator CAPER (RRM superfamily)  ali follow..  16  143.........................SPEERDARTVFCMQLAARIRPRDLEDFFSAVGKVRDVRII--SDRNSRRSKGIAYVEFCEIQSVPLAIGLTGQRLLGVPIIVQASQA.................................................................................................................................................................................................................................................................................................................................................................................... 227
58 -13.000[K] KOG1548 Transcription elongation factor TAT-SF1  ali follow..  10  106............................PVINKAVYIQGLPLDVTVDEIEEVFKKCGVIAKIKIYRTED---GTPKGDALIVFFRSESVELAEQFDDTEFRYGSGQKMRVQ..................................................................................................................................................................................................................................................................................................................................................................................... 194
59 -13.000[K] KOG4210 Nuclear localization sequence binding protein  ali follow..  18  238...............................SRILFVGNLSFDVTDDLLRKHFQHCGDIVKIRMATFEDS--GKCKGFAFIDFKNEEGSTNELKKSCRKIAGRPLRME........................................................................................................................................................................................................................................................................................................................................................................................ 313
60 -13.000[R] KOG1995 Conserved Zn-finger protein  ali follow..  15  276............................NCDNARIYISNLPPDVTTDELKDLFGGIGQVGRIKIYTDEK---GNYKGDACLAYEDPSAAHSAGGFNNYEMRGNKISVTMAE..................................................................................................................................................................................................................................................................................................................................................................................... 370
61 -12.800[A] KOG0131 Splicing factor 3b, subunit 4  ali follow..  13  16.......................QHSAERNQDATVYVGGLDAQLSEELLWELFVQAGPVVNVYVP--KDRVTNLHQNYGFIEYRSEEDADYAIKLNMIKLHGKPIRVNKASQDKKSLDVGAN.......................................................................................................................................................................................................................................................................................................................................................................... 113
62 -12.700[P] KOG4505 Na+/H+ antiporter  ali follow..  8  442......................................................................................................................................................................TLALSFTRTRDSHFAFNLPRVRQGQSLPIKRVDALRSSANSIASSIRRRHPVNIQEDEDADISTVSLPEAAHLREERAESPRGGHYDAEEFPSEDYESRQPRRSNEEDREEEMNPGDETYLIGEDLVVEDSQGNIISHTSSRDANGPSIDEKLAQGDPKAKSFGRKFRSFLRRSYDTFQRNLHEPDDERQREPTLGHIESSIENHRPRYSRQNSESHLRENSVERRRREQVLTNIGDSESEDDNIPRPGIVPFYNENNESSSDTRNGLLSDNVSESRSRRPSRAPSAAVSSEGSPVEEDNEAQHRPNIRFLELTRAWE 759
63 -12.500[AJ] KOG0123 Polyadenylate-binding protein (RRM superfamily)  ali follow..  12  2.......................NAAASSYPMASLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVC--RDMITRRSLGYAYVNFQQPADAERALTMNFDVIKGKPIRIMWSQRDPSLRKSGVGN......................................................................................................................................................................................................................................................................................................................................................................... 100
64 -12.400[A] KOG2548 SWAP mRNA splicing regulator  ali follow..  10  647...............................................................................................................................................................................NSEGSDNEEQQQPQLGKRAEDSDDMELDTASERSHALQPTMSSSSSTGNQTGKYSSATETGSGHPSSGGGGRPNLRERLKRKMQNLLNRQYKADKRAEIEKTERERLQQQEREDEMRELALKLRRRRRELRHKYGTPSSGKLSDSDAESVASESQLAKSSTRRSRSRSESRRRSPPPETQHSRRSSSRTERRRRTRTPSPKYNRRQRSRSRSGSRVERKRRSHSRRRSGSRDRRRSRSRRSQSRRRRQRDRSIERNREREQYRQQHQQQNERLRGRDRDREADYGHGGSGSSNRGRVVISAPPKLKKLV 955
65 -12.400[A] KOG0115 RNA-binding protein p54nrb (RRM superfamily)  ali follow..  18  118..................................LFVGNLPNEVKETELKELFSPHGDIAECYLS---------GKGFAFLRLDTRAHAESAKAIDGRIIHGRQVRVRFAVH.................................................................................................................................................................................................................................................................................................................................................................................... 187
66 -12.100[A] KOG4211 Splicing factor hnRNP-F and related RNA-binding proteins  ali follow..  17  4.........................GTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN.................................................................................................................................................................................................................................................................................................................................................................................... 90
67 -11.900[K] KOG3152 TBP-binding protein, activator of basal transcription (contains rrm motif)  ali follow..  17  51.................................VCYLSRIPPHMDHVRLRHILAQYGELGRIYLAPRAGGFRGQRFSEGWVEFAKKSVAKVADMLNGEQIGGK............................................................................................................................................................................................................................................................................................................................................................................................. 140
68 -11.600[K] KOG2821 RNA polymerase II transcription elongation factor Elongin/SIII, subunit elongin A  ali follow..  8  80.............................................................................................................................................................................RNAEPDEQDFEKSNSRKRPRDALQKEEEMEGDYQETWKATGSRSYSPDHRQKKHRKLSELERPHKVSHGHERRDERKRCHRMSPTYSSDPESSDYGHVQSPPSCTSPHQMYVDHYRSLEEDQEPIVSHQKPGKGHSNAFQDRLGASQERHLGEPHGKGVVSQNKEHKSSHKDKRPVDAKSDEKASVVSREKSHKALSKEENRRPPSGDNAREKPPSSGVKKEKDREGSSLKKKCLPPSEAASDNHLKKPKHRDPEKAKLDKSKQGLDSFDTGKGAGDLLPKVKEKGSNNLKTPEGKVKTNLDRKSLGSLPK 390
69 -11.500[R] KOG0151 Predicted splicing regulator, contains RRM, SWAP and RPR domains  ali follow..  8  746............................................................................................................................................................................................................................................................................VKKEKIDLILPTSRWAREDDETDDEQKKSYSSGSDNAGGITFKTDEEDLKADPSVRVQPENEIDVEQRQKLRHIEIALIEYRESLEEQGMKNSEEIERKVAIHRKRLEADGLSGNQRVLPEKREKREDSRDSSRKRNRSESQNRSQSPPQKSLTRERVRDHDLDKDRHRDRDRQQHDLDKDRKRRAKSSSRERDDHDRSRERDRDWRRRGMR.... 957
70 -11.500[S] KOG4843 Uncharacterized conserved protein  ali follow..  7  253................................................................................................................................................................................TRDTKFDRENQNYNEQKGEIKMEKEGHAHLAWKEQKDYHRGKRVAEGSTANVDPWVVSRGNPQGPTEVGPKDLSAPVEGSHLEGRETVGENKVDAKNEDRFKEKDKKRKELKHREWGDRDKDRNDRRVSVLVGSVMSEPKEIGREERESDRWERERMEQKDRERNKEKDKDHIKREPRTGAEKEISQNEKELGEASAKPSEQEYVAPEQKKQNEPDNCEKDERETKEKRRERDGDSEAERAEKRSRISEKESEDGCLEGEGATEREKDAFNYGVQQRKRALRPRGSPQTTNRDNVRSRSQDNEGVQGN 560
71 -11.300[A] KOG0117 Heterogeneous nuclear ribonucleoprotein R (RRM superfamily)  ali follow..  22  58..................................IFIGKLPRDLFEDELIPLCEKIGKIYEMRMMMDFN---GNNRGYAFVTFSNKVEAKNAIKLNNYEIRNGRLLGV........................................................................................................................................................................................................................................................................................................................................................................................ 129
72 -11.200[A] KOG1996 mRNA splicing factor  ali follow..  21  305............................KCPTKVVLLRNMGAGEVDEDLEV--EKYGKVGKCVIFEIPGAPDDEAVRI-FLEFERVESAIKAVVLNGRYFGGRVVKAC........................................................................................................................................................................................................................................................................................................................................................................................ 389
73 -11.100[K] KOG2068 MOT2 transcription factor  ali follow..  10  108...............................RNLVYIVGLPLNLADEDLKEYFGQYGKVLKVSMSRTATGLIQQFPNSVYITYGKEEEAIRCIQVHGFILDGKALKAC........................................................................................................................................................................................................................................................................................................................................................................................ 191
74 -11.000[T] KOG2370 Cactin  ali follow..  11  2.............................................................................................................................................................................................................................................................................................GKDSKKHKKERRRERSPSTSDSDEERLQKRLAEQRSLKKDEKRRQKEEMKKNESAEEKRARRMEKKMRKDAKRKDADAEDTLIPPELNYTNLNNPFNDTKLTQTFVWGKKLEREGKSGLTQDEITKQTSQRIRKNLHEAAEFKRIRDSRAAAKEDMEMMKRDADLRAGQISDTKEREFQMDQIKERTRIRIDQGRAK.. 198
75 -11.000[R] KOG4733 FOG: RRM domain  ali follow..  15  50....................SSSNSGWDQLSKTNLYIRGLPPHTTDQDLVKLCQPYGKIVSTKAI--LDKTTNKCKGYGFVDFDSPAAAQKAVSLKASGVQAQMAKQQEQDP.................................................................................................................................................................................................................................................................................................................................................................................... 140
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Jaroszewski L, Godzik A. Sequence clustering strategies improve remote homology recognitions while reducing search times. Protein Eng. 2002 Aug;15(8):643-9.